Polymorphisms in MTHFR, MTR, RFC1 and CßS genes involved in folate metabolism and thyroid cancer: a case-control study
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چکیده
منابع مشابه
Folate Levels and Polymorphisms in the Genes MTHFR, MTR, and TS in Colorectal Cancer
AIM The aim of the study was to explore and describe the effect of polymorphisms in folate-associated genes regarding the levels of different folate forms and their distribution in tumors and mucosa in patients with colorectal cancer. MATERIALS AND METHODS Tumor and mucosa tissues from 53 patients with colorectal cancer were analyzed. The concentrations of tetrahydrofolate (THF), 5-methylTHF,...
متن کاملGene-Gene Interaction Study Between Genetic Polymorphisms of Folate Metabolism and MTR SNPs on Prognostic Features Impact for Breast Cancer
Background: Breast Cancer (BC), the second leading cause of cancer mortality after lung cancer and varied across the world due to genetic and environmental factors. In this study, we evaluated the interaction between the polymorphisms in genes encoding enzymes of folate metabolism: methylenetetrahydrofolate reductase (MTHFR), methionine synthesis reductase (MTR) with the BC prognostic factors. ...
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منطقه ی آسیای مرکزی وقفقاز به عنوان منطقه ای تاریخی و به دلیل دارا بودن ذخایر عظیم هیدرو کربنی از اهمیت ویژه ای برخوردار است. کشورهای این منطقه از عوامل عمده ی بی ثباتی نظیر عوامل جغرافیایی، اقتصادی، امنیتی، اجتماعی و سیاسی رنج می برند. پس از فروپاشی اتحاد جماهیر شوروی کشورهای منطقه از نعمت استقلال ناخواسته ای برخوردار شدند که مشکلات فوق را برای آن ها چندین برابر می کرد. در این روند برخی از این...
15 صفحه اولCase-control study of ovarian cancer and polymorphisms in genes involved in catecholestrogen formation and metabolism.
Steroid hormones, such as estrogens, appear to be associated with ovarian carcinogenesis, but the precise biological mechanisms are unclear. Polymorphisms in genes that regulate the concentration of estrogens and their metabolites may contribute directly to the individual variation in ovarian cancer risk through a mechanism involving oxidative stress or indirectly by influencing ovarian cancer ...
متن کاملMTHFR and MTR Polymorphisms and Breast Cancer in Brazilian Women
Breast cancer (BC) is the second most common cancer, and mortality rates remain high among Brazilian women. However, the role of single nucleotide polymorphisms (SNPs) in one-carbon metabolism genes in breast cancer in Brazilian women is less clear. We aimed examine the association between the SNPs, in two genes in one-carbon metabolism alone and in cumulation, and the risk of breast cancer in ...
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ژورنال
عنوان ژورنال: Archives of Medical Science
سال: 2019
ISSN: 1734-1922
DOI: 10.5114/aoms.2018.73091